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ORIGINAL ARTICLE
Year : 2014  |  Volume : 5  |  Issue : 2  |  Page : 123-126

Learning and memory enhancing activity of Ficus carica (Fig): An experimental study in rats


Department of Pharmacology, Visveswarapura Institute of Pharmaceutical Sciences, Bengaluru, Karnataka, India

Correspondence Address:
Meera Sumanth
Department of Pharmacology, Visveswarapura Institute of Pharmaceutical Sciences, 22nd Main, 24th Cross, Banashankari 2nd Stage, Bengaluru - 560 070, Karnataka
India
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Source of Support: None, Conflict of Interest: None


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Objective: The study aimed to assess the learning and memory enhancing activity of the ethanolic fruit extract of Ficus carica in rats using elevated plus maze (EPM), Hebb-William maze (HWM) and Morris water maze (MWM). Materials and Methods: Wistar rats (100-150 g) of either sex, were divided into 5 groups (n = 6). Group I (control) animals received vehicle, Group II (scopolamine control) animals received scopolamine (0.4 mg/kg i.p), Groups III and IV animals received ethanolic fruit extract of F. carica (200 mg/kg and 400 mg/kg p.o) and Group V animals received piracetam (400 mg/kg i.p) for 27 days. The rats of Groups III-V were injected with a single dose of scopolamine (0.4 mg/kg i.p) on 19 th and 27 th day. Assessment of transfer latency (TL), time taken to reach reward chamber (TRC) and swim latency (SL) was done on 19 th and 27 th day using EPM, HWM and MWM, respectively. The data was analyzed by one-way Analysis of Variance followed by Dunnett's test. P ≤ 0.05 was considered to be significant. Results: Ethanolic fruit extract of F. carica decreased TL, TRC and SL in comparison to scopolamine treated rats. Conclusion: The fruit of F. carica enhanced learning and memory activity.


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