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ORIGINAL ARTICLE
Year : 2014  |  Volume : 5  |  Issue : 2  |  Page : 127-133

Assessment of locomotion behavior in adult Zebrafish after acute exposure to different pharmacological reference compounds


1 Drug Safety Evaluation, Ranbaxy Research Laboratories, Gurgaon, Haryana; Central Research Institute for Homoeopathy, Drug Standardisation Unit, Noida, Uttar Pradesh, India
2 Drug Safety Evaluation, Ranbaxy Research Laboratories, Gurgaon, Haryana, India
3 Laboratory Animal Medicine Unit, Tamil Nadu Veterinary and Animal Sciences University, Chennai, Tamil Nadu, India

Correspondence Address:
Pankaj Gupta
Research Officer (Pharmacology), Central Research Institute for Homoeopathy, Sec-24, Noida - 201 301, Uttar Pradesh
India
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Source of Support: Ranbaxy Research Laboratories., Conflict of Interest: None


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Objectives: The objective of the present study was to assess locomotor behavior of adult zebrafish after acute exposure to different pharmacological reference compounds. Materials and Methods: Adult zebrafish of 4-5-months-old were exposed to different concentrations of known reference compounds for 15 min. The test was conducted separately for each drug concentration as well as control. Locomotor activity parameters viz. distance travelled, speed, total mobile time, and total immobile time were recorded for each animal during the exposure period. Results: Out of 11 compounds tested, nine compounds showed decrease in locomotor behavior with significant changes in distance travelled, speed, total mobile time, and total immobile time. Caffeine exhibited biphasic response in locomotion behavior, while scopolamine failed to induce any significant changes. Conclusion: In view of the above findings, these results suggested that exposure of adult zebrafish with different known compounds produce the expected changes in the locomotion behavior; therefore, adult zebrafish can be used an alternative approach for the assessment of new chemical entities for their effect on locomotor behavior.


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