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ORIGINAL ARTICLE
Year : 2015  |  Volume : 6  |  Issue : 2  |  Page : 93-100

Hepatoprotective effects of aqueous root bark extracts of Anogeissus leiocarpus, Terminalia avicennioides, and their mixture in diethylnitrosamine-treated rats


1 Department of Chemical Sciences, Biochemistry and Nutrition Unit, Antioxidants, Toxicology and Phytomedicine Research Laboratory, Fountain University, Osogbo, Nigeria
2 Department of Biochemistry, Phytomedicine, Toxicology, Reproductive and Developmental Biochemistry Research Laboratory, University of Ilorin, Ilorin, Nigeria

Correspondence Address:
Amadu Kayode Salau
Department of Chemical Sciences, Fountain University, P.M.B. 4491, Osogbo
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2394-6555.162454

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Introduction: This study investigated the hepatoprotective activity of aqueous root bark extracts of Anogeissus leiocarpus, Terminalia avicennioides, and their 1:1 mixture in diethylnitrosamine (DEN)-treated rats. Materials and Methods: Rats were orally pretreated with extracts and 1:1 mixture (200, 400, and 800 mg/kg body weight) for 2 weeks before being challenged with DEN (30 mg/kg body weight) once a week on weeks 3 and 4. Curcumin (200 mg/kg body weight) was used as reference antioxidant agent, and distilled water was used as a control. The whole experiment lasted for 4 weeks. The activities of liver and serum alkaline phosphatase (ALP), aspartate and alanine aminotransferases (AST and ALT), and gamma-glutamyltransferase (GGT), as well as the levels of serum total protein, albumin, total, and conjugated bilirubin were evaluated. Results: The extracts and their mixture significantly (P < 0.05) prevented the DEN-induced alterations in the activities of ALP, AST, ALT, and GGT in the liver and serum of the animals; as well as the altered levels of serum total and conjugated bilirubin. Conclusion: Overall, the results of this study revealed that the extracts possess hepatoprotective activities against DEN-induced liver damage in rats.


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