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REVIEW ARTICLE
Year : 2017  |  Volume : 8  |  Issue : 1  |  Page : 1-5

Mass spectrometry-based metabolomics in biomarker-assisted drug discovery and oxidative stress research


1 Department of Biochemistry and Clinical Pharmacology, National Institute for Research in Tuberculosis, Chennai, Tamil Nadu, India
2 Department of Biotechnology, Laboratory of Bioorganic Chemistry, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India

Correspondence Address:
V Sivaram
Department of Biochemistry and Clinical Pharmacology, National Institute for Research in Tuberculosis, Chetpet, Chennai - 600 031, Tamil Nadu,
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ddt.DDT_2_16

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Biomarker-assisted drug discovery is a major step in identification of drug efficacy and disease proliferation of both communicable and noncommunicable diseases. Biomarker-assisted drug discovery using metabolomics approach is now a reliable “path of opportunity” in drug discovery, as it offers precise insight into the efficacy of tested drug in the biological setup. With the advent of recent advances in instrumentation, accuracy and specificity of biomarker-based drug discovery program is improved. A key challenge in biomarker discovery is the choice of detection method, as diverse metabolites present in the physiological system pose varying levels of detection response with different instrumentation platforms. In biomarker-assisted early diagnosis, mass spectrometry-based metabolomics has a major advantage due to its capability of wide metabolite range coverage with great specificity. This review also discusses the advantage of biomarker-assisted discovery using metabolome analysis.


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