Drug Development and Therapeutics

SHORT COMMUNICATION
Year
: 2014  |  Volume : 5  |  Issue : 2  |  Page : 172--176

Modulation of solubility and dissolution of furosemide by preparation of phospholipid complex


Mona Semalty1, Prateeksha Badoni1, Devendra Singh2, Ajay Semalty1 
1 Department of Pharmaceutical Sciences, H. N. B. Garhwal University, Srinagar, Garhwal, Uttarakhand, India
2 Department of Chemistry, H. N. B. Garhwal University, Srinagar, Garhwal, Uttarakhand, India

Correspondence Address:
Dr. Ajay Semalty
Department of Pharmaceutical Sciences, H. N. B. Garhwal University, Srinagar, Garhwal - 246 174, Uttarakhand
India

Aim: The aim of this study is to improve the solubility and dissolution of furosemide (a potent high ceiling diuretic used for the treatment of hypertension and a Class IV drug that is low solubility and low permeability drug as per the Biopharmaceutical Classification System) by preparing its phospholipid complexes or pharmacosomes. Materials and Methods: Furosemide was complexed with phosphatidylcholine in four different molar ratios (1:1, 1:2, 1:3 and 1:4) by conventional solvent-evaporation technique. The pharmacosomes prepared were evaluated for drug content, solubility, X-ray powder diffraction (XRPD) and in-vitro dissolution study. Results: Pharmacosomes of furosemide showed high drug content ranging from 88.30% to 100%. XRPD studies confirmed the formation of phospholipid complex and the amorphization of drug in the complex. The water solubility was found to be increased up to six-fold in the complexes. The octanol solubility also increased in the complexes indicating the probable increase in permeability. The in-vitro dissolution profile of the prepared complexes was found to be much better than furosemide. Conclusion: It was concluded that the phospholipid complexes can be effectively used for improving the solubility, dissolution, permeability and hence the bioavailability of furosemide like Class IV drugs.


How to cite this article:
Semalty M, Badoni P, Singh D, Semalty A. Modulation of solubility and dissolution of furosemide by preparation of phospholipid complex.Drug Dev Ther 2014;5:172-176


How to cite this URL:
Semalty M, Badoni P, Singh D, Semalty A. Modulation of solubility and dissolution of furosemide by preparation of phospholipid complex. Drug Dev Ther [serial online] 2014 [cited 2020 Feb 19 ];5:172-176
Available from: http://www.ddtjournal.org/article.asp?issn=2394-6555;year=2014;volume=5;issue=2;spage=172;epage=176;aulast=Semalty;type=0